Which leukocyte does tb live in

Davis, C. Hall, P. Crosier, and L. Lee, J. Kang, J. Yan et al. Scapini, J. Lapinet-Vera, S. Gasperini, F. Calzetti, F. Bazzoni, and M. Petrofsky and L. Riedel and S. View at: Google Scholar S. Matzer, T. Baumann, N. Lukacs, M. Sawant and D. Hilda and S. Parks, C. Wilson, and Y. Immunology , vol. Sanchez-Hernandez, T. Geijtenbeek, and Y. Alfaro, N. Suarez, C.

Beauvillain, Y. Delneste, M. Scotet et al. Abi Abdallah, C. Egan, B. Butcher, and E. Duffy, H. Perrin, V. Abadie et al. Kalyan and D. Tillack, P. Breiden, R. Martin, and M. Bratton and P. Filardy, D. Pires, M. Nunes et al. Mantovani, M. Cassatella, C. Costantini, and S. Blomgran and J. Abadie, E. Badell, P. Douillard et al. Trentini, F. Kipnis, and A. Silva Miranda, A. Breiman, S. Allain, F.

Deknuydt, and F. Seiler, P. Aichele, S. Bandermann et al. Umemura, A. Yahagi, S. Hamada et al. Ishizuka, Y. Miyazaki, M. Masuo et al. Barry, H. Boshoff, V. Dartois et al. Microbiology , vol. Lin and J. Parker and C. McCracken and L. Keller, R. Hoffmann, R. Lang, S. Brandau, C. Hermann, and S. Driver, G. Ryan, D. Hoff et al. Marzo, C. Vilaplana, G. Tapia, J. Diaz, V. Garcia, and P. Niazi, N. Dhulekar, D. Schmidt et al. Smith, M. Proulx, A. Olive et al. Sutherland, D.

Jeffries, S. Donkor et al. Berry, C. Graham, F. McNab et al. Barry, R. Breen, M. Lipman, M. Johnson, and G. Ong, P. Elkington, S. Brilha et al. Choi, H. Chon, K. Kim et al. Schneider, D. Korbel, K. Hagens et al. Dorhoi, C. Desel, V. Yeremeev et al. Das, M. Koo, B. E—E, Desvignes and J. Nouailles, A. Dorhoi, M. Koch et al. Al Shammari, T. Shiomi, L. Tezera et al. Teixeira, M. Dias, R. Sales et al. Gopal, L. Monin, D. Torres et al. Ueda, D. Cain, M. Kuraoka, M. Kondo, and G.

Kimmey, J. Huynh, L. Weiss et al. Pedrosa, B. Saunders, R. Appelberg, I. Orme, M. Silva, and A. Appelberg, A. Castro, S. Gomes, J. Pedrosa, and M. Dorhoi, V.

Yeremeev, G. Nouailles et al. Henao-Tamayo, I. Orme, and D. Tsiganov, E. Verbina, T. Radaeva et al. Knaul, S. Oberbeck-Mueller et al. Loebenberg, M.

Kriel et al. El Daker, A. Sacchi, M. Tempestilli et al. Hestdal, F. Ruscetti, J. Ihle et al. Satake, H. Hirai, Y. Hayashi et al. Wright, F. Makki, R. Moots, and S. Denny, S. Gould on Twitter. Already a subscriber? Sign in. Thanks for reading Scientific American. Create your free account or Sign in to continue. See Subscription Options. Go Paperless with Digital. A recent paper in PloS reference below shows that in order to do this, the TB must break out of the vacuole holding it following ingestion, and then kill the host cell once it's in the cytoplasm: This model is not a fully accepted one within the TB community, and there's still some conflict as to whether the bacterium actually breaks out of the vacuole it gets ingested into as shown above or whether it stays within the vacuole and wrecks havoc from there.

Image 2 c me. Linkback if you want to borrow it. Gould on Twitter Recent Articles by S. Get smart. Sign up for our email newsletter. Sign Up. Read More Previous.

Support science journalism. This way they can thrive and divide," Flo says. But if we could prevent mycobacteria from hiding in this compartment, or force the bacteria out of it, they would have a hard time not being killed. Then it would have trouble causing a chronic infection," she said. An important lead may be that not all mycobacteria manage to avoid being detected. The macrophages engulf all the bacteria, but only the most well-adapted ones are not discovered and manage to hide and survive.

The researchers envision future research where they would try to find out how the mycobacteria manage to establish and sustain the vesicle hideouts as they evade discovery. That would enable something to be done about these chronic infectors. The treatment for common tuberculosis usually involves four different antibiotics to start, and gradually decreases to two. The whole process takes about six months.

But if the tuberculosis bacterium is resistant to antibiotics, recovery can take up to two years. You can become infected and sick again, so it's important to find solutions that can provide milder, shorter-term treatment," says Flo. Antibiotics are designed to kill bacteria. Antibiotic resistance is an increasing problem.

An effective solution may be to combine antibiotics with substances that stimulate our own immune system. In this way, the bacteria would be attacked from two sides and would therefore have a harder time finding places to hide.

Note: Content may be edited for style and length. Science News. ScienceDaily, 3 October How tuberculosis hides in the body.